What is modafinil, and how does it work (mechanism of action)?

• Posted by ema hossain December 17, 2022 - Filed in Health - #health  #doctor  - 79 views

  

  Modafinil is an oral medication which is utilized for improving wakefulness in individuals with too much sleepiness. It's akin to armodafinil (Nuvigil). Just like amphetamines, modafinil stimulates wakefulness by stimulating the human brain. The actual mechanism of action of modafinil is unknown. It might work by boosting the quantity of dopamine (a substance neurotransmitter which nerves work with to speak with each other) in the mind by decreasing the reuptake of dopamine into nerves. Modafinil was authorized by the FDA in December 1998.

  What brand names are out there for modafinil?
  Provigil

  Is modafinil offered as a generic drug?
  GENERIC AVAILABLE: Yes

  Do I want a prescription for modafinil?
  Yes

  
  What exactly are the unwanted side effects of modafinil?
  The most popular unwanted side effects of buy modalert include:

  headache,
  upper respiratory tract infection,
  nausea,
  nervousness,
  nervousness, insomnia and.

  What exactly are the applications for modafinil?
  Modafinil is utilized to advertise wakefulness in individuals with too much sleepiness related to narcolepsy, obstructive sleep apnea (in addition to treatment of the basic obstruction), and also shift work sleep disorder. Narcolepsy is a chronic illness of spinal cord and the brain characterized most often by a recurrent, uncontrollable need to sleep. Shift work sleep disorder is an ailment where the standard rhythm of sleep is disrupted, usually as an outcome of working at night. Sleep apnea is a condition where sleep is continually interrupted during the night due to pauses in breathing or maybe breathing that is shallow often because of obstruction of top of the airway.

  What's the dosage for modafinil?
  The recommended dose is 200 mg once daily never to exceed 400 mg. It must be administered in the early morning for managing obstructive sleep apnea or narcolepsy, along with one hour before operate in all those with shift work disorder. It may be taken with or with no food. The 400 mg dose might not be better compared to 200 mg dose.

  What supplements or drugs communicate with modafinil?
  Modafinil is able to lessen or even boost the activity of enzymes in the liver which metabolize (eliminate) various other drugs. This could lead to decreased levels of certain drugs which reduce the effectiveness of theirs and increased levels of various other drugs which leads to the toxicity of theirs. Modafinil treatment must be thoroughly monitored if taken with all of these drugs. Drugs which might have decreased effectiveness if taken with modafinil include cyclosporine (Sandimmune), theophylline, and then hormonal contraceptives such as for instance progestin only or maybe estrogen and progesterone with medications (for instance, Micronor, Ortho Novum 1/50). Alternative hormonal contraceptives or even a further non drug form of contraception might be of interest during treatment with modafinil, and therapy must remain for just one month after modafinil therapy ends (since the influences of modafinil on contraceptive hormones might continue for many weeks). The consequences of modafinil on hormonal contraceptives occurs if the stress hormones are taken by mouth, spot, or maybe implant.

  Medications which could reveal increased toxicity or effects if taken with modafinil include warfarin (Coumadin), diazepam (Valium), propranolol (Inderal), imipramine (Tofranil), desipramine (Norpramin), phenytoin (Dilantin) and mephenytoin (Mesantoin).

  Various other drugs which might improve the effectiveness or toxicity of modafinil. These medications consist of carbamazepine (Tegretol), phenobarbital, and also rifampin (Rifadin).

  Some other medicines, for example ketoconazole (Nizoral) and itraconazole (Sporanox) may lessen the effectiveness of modafinil. Methylphenidate might postpone the action of modafinil.

  The result of alcohol on modafinil hasn't been properly evaluated. Alcohol possibly should be stayed away from while taking modafinil. 

  Author: Dr. Mevan Nandaka Wijetunga, MD
  Specialities: Cardiovascular Disease Condition Treatment: Atrial Flutter, Cardiomyopathy, Cerebrovascular Disease, Heart Disease, Stroke, Vascular Disease